How Kleeb Bua Daeng Benefits Sleep Disorders

How Kleeb Bua Daeng Benefits Sleep Disorders

Introduction

Sleep disorders, such as insomnia, are closely associated with chronic stress, inflammation, and disrupted brain function. Kleeb Bua Daeng (KBD), a Thai traditional herbal formula, demonstrates multiple pharmacological actions that address these underlying causes. This makes it a promising natural remedy for improving sleep quality.

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1. Stress Reduction and HPA Axis Regulation

• Chronic stress activates the Hypothalamic-Pituitary-Adrenal (HPA) axis, leading to cortisol dysregulation, which disrupts sleep cycles.
• KBD normalizes HPA axis function by:
  • Upregulating glucocorticoid receptor (GR) expression.
  • Reducing FKBP5 and SGK1 levels, which are associated with prolonged stress and impaired HPA feedback.
• By reducing stress responses, KBD alleviates one of the most significant contributors to insomnia.

Key Point: Stress reduction promotes better sleep onset and duration.

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2. Promoting Neurogenesis and Brain Health

• KBD enhances neuroplasticity and supports brain health by:
  • Increasing BDNF (Brain-Derived Neurotrophic Factor) and CREB expression in the hippocampus and frontal cortex.
  • These proteins are crucial for mood stabilization, memory, and overall brain function.
• Healthy brain function is essential for maintaining a regular and restorative sleep cycle.

Key Point: Improved neurogenesis helps restore natural sleep patterns.

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3. Anti-Inflammatory Effects

• Sleep disorders are often linked to neuroinflammation caused by stress or underlying conditions.
• KBD significantly reduces the expression of proinflammatory cytokines, including:
  • IL-1β, IL-6, and TNF-α, which are elevated in individuals with poor sleep quality.
• Lowering inflammation in the brain creates a healthier environment for sleep.

Key Point: Anti-inflammatory action reduces sleep disturbances linked to inflammation.

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4. Monoamine Regulation

• Neurotransmitter imbalances, especially serotonin, dopamine, and norepinephrine, are associated with insomnia and disrupted sleep.
• KBD and its components inhibit Monoamine Oxidase (MAO) enzymes, which enhances the levels of these neurotransmitters.
• Specifically:
  • N. nucifera shows selective MAO-A inhibition, supporting antidepressant and sleep-regulating effects.

Key Point: Balanced neurotransmitter levels improve mood and promote restorative sleep.

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5. Traditional Use for Insomnia

• KBD has been used for decades in Thai traditional medicine to promote brain health and relieve insomnia.
• Its combination of three herbal components—Centella asiatica, Piper nigrum, and Nelumbo nucifera—synergistically targets stress, inflammation, and neurotransmitter imbalances.

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Conclusion

By reducing stress, supporting brain health, regulating inflammation, and balancing neurotransmitters, Kleeb Bua Daeng addresses the core mechanisms contributing to sleep disorders. This evidence highlights its potential as an effective and natural remedy for individuals struggling with sleep disturbances, particularly those caused by stress or depression.

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Supporting Evidence

The findings are supported by preclinical studies that demonstrate KBD's multi-target effects in chronic stress-induced models, emphasizing its role in:

1. Stress reduction and HPA axis regulation.
2. Neurogenesis through BDNF and CREB activation.
3. Anti-inflammatory and MAO inhibitory actions.

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